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PUBLICATIONS

  1. Weiss G, Lai C, Fife ME, Grabiec AM, Tildy B, Snelgrove RJ, Xin G, Lloyd CM, Hussell T. Reversal of TREM-1 ectodomain shedding and improved bacterial clearance by intranasal metalloproteinase inhibitors. Mucosal Immunol 2016; doi: 10.1038/mi.2016.104. [Epub ahead of print]
  2. Angiolilli C, Kabala PA, Grabiec AM, Van Baarsen IM, Ferguson BS, García S, Malvar Fernandez B, McKinsey TA, Tak PP, Fossati G, Mascagni P, Baeten DL, Reedquist KA: Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes. Ann Rheum Dis 2017;76(1):277-285.
  3. Hussell T, Grabiec AM: Immunopathology of lung diseases: introduction for the special issue. Semin Immunopathol 2016;38(4):407-8.
  4. Grabiec AM, Hussell T: The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation. Semin Immunopathol 2016; doi: 10.1007/s00281-016-0555-3.
  5. Angiolilli C*, Grabiec AM*, Ferguson BS, Ospelt C, Malvar Fernandez B, van Es IE, van Baarsen LG, Gay S, McKinsey TA, Tak PP, Baeten DL, Reedquist KA: Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression. Ann Rheum Dis 2016;75(2):430-8. *contributed equally
  6. Klein K, Kabala PA, Grabiec AM, Gay RE, Kolling C, Lin LL, Gay S, Tak PP, Prinjha RK, Ospelt C, Reedquist KA: The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts. Ann Rheum Dis 2016;75(2):422-9.
  7. Fujimori T*, Grabiec AM*, Kaur M, Bell TJ, Fujino N, Cook PC, Svedberg FR, MacDonald AS, Maciewicz RA, Singh D, Hussell T. The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung. Mucosal Immunol 2015;8(5):1021-30. *contributed equally
  8. Grabiec AM*, Angiolilli C*, Hartkamp LM, van Baarsen LG, Tak PP, Reedquist KA: JNK-dependent downregulation of FoxO1 promotes the survival of fibroblast-like synoviocytes in rheumatoid arthritis. Ann Rheum Dis 2015;74(9):1763-71. *contributed equally
  9. Grabiec AM, Reedquist KA: The ascent of acetylation in the epigenetics of rheumatoid arthritis. Nat Rev Rheumatol 2013;9(5):311-8.
  10. Grabiec AM, Korchynskyi O, Tak PP, Reedquist KA: Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay. Ann Rheum Dis 2012;71(3):424-31.
  11. de Launay D, van de Sande MG, de Hair MJ, Grabiec AM, van de Sande GP, Lehmann KA, Wijbrandts CA, van Baarsen LG, Gerlag DM, Tak PP, Reedquist KA: Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): a prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets. Ann Rheum Dis 2012;71(3):415-23.
  12. Grabiec AM, Tak PP, Reedquist KA: Function of histone deacetylase inhibitors in inflammation. Crit Rev Immunol 2011;31(3):233-263.
  13. de Launay D, Vreijling J, Hartkamp LM, Karpus ON, Abreu JR, van Maanen MA, Sanders ME, Grabiec AM, Hamann J, Orum H, Vervoordeldonk MJ, Fluiter K, Tak PP, Reedquist KA: Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis. Am J Pathol 2010;177(6):3010-24.
  14. Grabiec AM, Reedquist KA: Histone deacetylases in RA: epigenetics and epiphenomena. Arthritis Res Ther 2010;12:142.
  15. Abreu JR, Krausz S, Dontje W, Grabiec AM, de Launay D, Nolte MA, Tak PP, Reedquist KA: Sustained T cell Rap1 signaling is protective in the collagen-induced arthritis model of rheumatoid arthritis. Arthritis Rheum 2010;62(11):3289-99
  16. Grabiec AM, Krausz S, de Jager W, Burakowski T, Groot D, Sanders ME, Prakken BJ, Maslinski W, Eldering E, Tak PP, Reedquist KA: Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue. J Immunol 2010;184 (5):2718-28.
  17. Abreu JR, de Launay D, Sanders ME, Grabiec AM, van de Sande MG, Tak PP, Reedquist KA: The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue. Arthritis Res Ther 2009;11:R121.
  18. Abreu JR, Grabiec AM, Krausz S, Spijker R, Burakowski T, Maslinski W, Eldering E, Tak PP, Reedquist KA: The presumed hyporesponsive behavior of rheumatoid arthritis T lymphocytes can be attributed to spontaneous ex vivo apoptosis rather than defects in T cell receptor signaling. J Immunol 2009;183(1):621-30.
  19. Grabiec AM, Tak PP, Reedquist KA: Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on? Arthritis Res Ther 2008;10:226.